Our gene editing projects involve the use of CRISPR/Cas. This is an innovative tool that allows gene editing through the precise targeting of specific DNA sequences. In KHEIRON BIOTECH, gene editing is used to introduce wild type genes of interest in different animals within a species (as naturally found in nature), without exogenous DNA sequences. By this strategy, the process is completely safe and the edited animals are non-transgenic. Therefore, an animal edited in KHEIRON BIOTECH is genetically identical to an animal that could be obtained by traditional breeding with the desired genotype in one generation.
Animal husbandry aims to improve phenotypic features of new generations. However, decades of animal crossings are necessary for the introduction of specific sequences of interest. Our gene editing strategy combined with cloning technology allow the introduction of genetic traits in one generation in a non-random way. This "Precise Genetic Progress" represents an improvement on the genetic selection of the animals, as it enables a fast and precise method to acquire advantageous features.
Gene editing combined with cloning technology will expand the potential of equine performance in sportive animals. In KHEIRON BIOTECH, we aim to improve muscle growth, endurance and speed in horses. Moreover, gene editing also holds the potential for repairing abnormal DNA sequences and correct genetic diseases.
Gene editing combined with cloning represent a state-of-the-art technology that enable "humanizing" porcine cells and having a potentially unlimited source of tissues and organs for clinical transplantation. This breakthrough in regenerative medicine is achieved by the precise editing of porcine genes to minimize antibody-mediated rejection.
Livestock with higher muscle mass results in higher protein content and live weight, which means better meat production efficiency. This also guarantees improved feed conversion efficiency, resulting in a significant advantage for agricultural producers. This characteristic can be obtained with the low or null expression of the myostatin gene. Based on the genetic sequence of breeds that naturally have higher protein content, in KHEIRON BIOTECH we are currently editing the DNA information of local breeds to increase the cattle productivity in our region.
Our final goal is to obtain different genetically-modified cloned rodeos with specific characteristics such as increased protein content, disease resistance, higher animal welfare and plasticity to adverse weather conditions.